6/20/2023 0 Comments Protein scaffold 3d printing![]() Together, these results suggest that 3D printing technology-based multi-dosing of insulin on demand can enable convenient treatment of diabetes through external NIR irradiation, potentially avoiding the pain and discomfort of repeated insulin injections.ģD printing On-demand delivery Protein drug Pulsatile multi-dose Remotely controlled delivery.Ĭopyright © 2022 Elsevier B.V. et al., 2020) and provides control over scaffold pore shape, size (Ghorbani et al. 3D printed scaffolds can be precisely designed to mimic bone tissue morphologically (Wang C. When the insulin-loaded multiunit implant was applied to a mouse diabetic model and irradiated with NIR, repetitive insulin release resulted in an efficient decrease of the blood glucose level over multiple days. 3D printing is an advantageous method to fabricate implantable scaffolds for bone regeneration. When lauric acid was absent from the matrix, the NIR-irradiated unit did not undergo dismantling. ![]() In the absence of melanin in the matrix, the implant did not show NIR-responsive insulin release. Irradiation with near infrared light (NIR) triggered controlled release of insulin from the irradiated locus: Upon NIR irradiation, heat generated from the melanin melted the polycaprolactone/lauric acid matrix to release insulin from the scaffold. The 3D printing yielded a rectangular matrix with multiunit sectors segregated by polycaprolactone lanes. ![]() As a model drug, insulin was loaded to each unit of the implant. Multiunit implants were designed to be 3D printed using polycaprolactone, lauric acid, and melanin as a matrix, and a polycaprolactone scaffold as a multiunit divider. Here, we constructed 3D-printed multiunit implants to enable remote light-controlled protein drug delivery in a spatiotemporal manner. Electrohydrodynamic printing (EHDP) is capable of fabricating scaffolds that consist of micro/nano scale orientated fibers for three-dimensional (3D) cell culture models and drug screening applications.
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