6/19/2023 0 Comments Retraction artifact meaningThe transition zone between BCC and SCC may or may not exist and has a fibroblast-rich and collagenized stroma. SCC areas are characterized by large polygonal squamoid cells with eosinophilic cytoplasm reflecting cytoplasmic keratinization, larger open nuclei with prominent nucleoli, frequent mitosis, dyskeratotic cells, and intercellular bridges. Basaloid cells are mitotically more active than indolent growth BCC, with greater numbers of apoptotic nuclei. In contrast to pure BCC, some basaloid cells in BSC have eosinophilic cytoplasm, often lack the characteristic peripheral palisading and retraction artifact and exhibit variable cytoplasmic keratinization. The BSC areas have small, uniform, hyperchromatic cells, with peripheral palisading mitoses and stromal collagen deposition with proliferative fibroblasts. The diagnosis of the present case was BSC, with a transition zone between BCC and SCC. These groups of tumors are classified as BSCs. Some tumors, however, are intermediate in their histology, while others are somewhat variable from one microscopic field to another. Many malignant skin tumors are easily classified as either classic BCC or SCC, with the correct prediction of their biological behavior. The patient has been followed up, and after 6 months, with no sign of further disease. The squamoid component exhibited dyskeratotic cells and metastatic cells invading blood vessels. The transition zone, which appeared abruptly, had intermediate cells and was between the BCC and SCC areas. The SCC component exhibited frequent atypical mitosis, cell and nuclear pleomorphism and hyperchromatism of the nuclei. The areas had BCC, with large and rounded basaloid cells, and SCC, with polygonal squamoid cells with abundant eosinophilic cytoplasm, large nuclei, and prominent nucleoli. Histological analysis with hematoxylin and eosin (H and E) stain revealed multiple islands of malignant cells throughout the dermis, exhibiting both basaloid and squamous differentiation. Seven years later, a local recurrence was widely excised and histological analysis confirmed BSC. Histological analysis revealed a partially excised BCC. A 63-year-old Caucasian male had a sessile lesion removed from his left ear.
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